Terence McKenna

Publisher: Bantam Books (1993)

The indole families of compounds that are strong visionary hallucinogens and also occur in plants are four in number: \r\n\r\n1. The LSD‑type compounds. Found in several related genera of morning glories and ergot, the LSD hallucinogens are rare in nature. That they are the best known of the hallucinogens is undoubtedly due to the fact that millions of doses of LSD were manufactured and sold during the 1960s. LSD is a psychedelic, but rather large doses are necessary to elicit the hallucinogenic paradise artificially, of vivid and utterly transmundane hallucinations, that is produced by DMT and psilocybin at quite traditional doses. Nevertheless, many researchers have stressed the importance of the non-hallucinogenic effects of LSD and other psychedelics. These other effects include a sense of mind expansion and increased speed of thought; the ability to understand and to relate to complex issues of behavior, life patterning, and complex, decision‑making networks of connective linkage. LSD continues to be manufactured and sold in larger amounts than any other hallucinogen. It has been shown to aid in psychotherapy and the treatment of chronic alcoholism: 'Wherever it has been tried, all over the world, it has proved to be an interesting treatment for a very old disease. No other drug so far has been able to match its record in salvaging tormented lives from the alcoholic scrap heap, directly, as a treatment, or indirectly, as a means of yielding valuable information.'' Yet, as a consequence of media hysteria its potential may never be known. \r\n\r\n2. The tryptamine hallucinogens, especially DMT, psilocin, and psilocybin. Tryptamine hallucinogens are found throughout the higher plant families, for example, in legumes, and psilocin and psilocybin occur in mushrooms. DMT also occurs endogenously in the human brain. For this reason, perhaps DMT should not be thought of as a drug at all, but DMT intoxication is the most profound and visually spectacular of the visionary hallucinogens, remarkable for its brevity, intensity, and nontoxicity. \r\n\r\n3. The beta ‑carbolines. Beta‑carbolines, such as harmine and harmaline, can be hallucinogenic at close to toxic levels. They are important for visionary shamanism because they can inhibit enzyme systems in the body that would otherwise depotentiate hallucinogens of the DMT type. Hence beta‑carbolines can be used in conjunction with DMT to prolong and intensify visual hallucinations. This combination is the basis of the hallucinogenic brew ayahuasca or yage, in use in Amazonian South America. Beta‑carbolines are legal and until very recently were virtually unknown to the general public. \r\n\r\n4. The ibogaine family of substances. These substances occur in two related African and South American tree genera, Tabernanthe and Tabernamontana. Taber nanthe iboga is a small, yellow flowered bush which has a history of usage as a hallucinogen in tropical West Africa. Its active compounds bear a structural relationship to beta‑carbolines. Ibogaine is known more as a powerful aphrodisiac than as a hallucinogen. Nevertheless, in sufficient doses it is capable of inducing a powerful visionary and emotional experience.